The first total synthesis of (+)-mucosin.
نویسندگان
چکیده
The first total synthesis of (+)-mucosin has been completed allowing assignment of the absolute stereochemistry of the natural product. A zirconium induced co-cyclisation was utilised to install the correct stereochemistry of the four contiguous stereocentres around the unusual bicyclo[4.3.0]nonene core.
منابع مشابه
Stereopermutation on the Putative Structure of the Marine Natural Product Mucosin.
A stereodivergent total synthesis has been executed based on the plausibly misassigned structure of the unusual marine hydrindane mucosin (1). The topological connectivity of the four contiguous all-carbon stereocenters has been examined by selective permutation on the highlighted core. Thus, capitalizing on an unprecedented stereofacial preference of the cis-fused bicycle[4.3.0]non-3-ene syste...
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عنوان ژورنال:
- Chemical communications
دوره 48 28 شماره
صفحات -
تاریخ انتشار 2012